ABSTRACT
The purpose of this article was to review current literature on the usage of denture bases as potential drug-release devices DRDs] for the treatment of oral conditions such as Candida associated denture stomatitis [CAD] and recurrent ulcers. Relevant publications from the year 1983 to 2014 were included by searching 'denture bases' and 'drug delivery' using [MeSH terminology]. Specific inclusion and exclusion criteria were set. Most studies were done in vitro. It was concluded during the review that various therapeutic agents such as Fluconazole, Chlorhexidine gluconate and Hydrocortisone Sodium Succinate have been successfully incorporated in denture base resins. Drugs leach out steadily from poly methyl methacrylate [PMMA] specimens for a period of 28 days. In case of rechargeable denture bases, the elution continues for longer periods. A lot of ongoing research is being done on the incorporation of silver nanoparticles and monitoring its antimicrobial activity
ABSTRACT
[It is submitted that the list of the published articles available on the Pubmed database were extracted using the key words [Osteogenesis and Bioglass] on 3rd April, 2015 followed by extraction of the full text articles from different sources and then thorough review of all the articles was done in 4 months' time period [from April to July 2015] to reproduce this manuscript. Authros]. Bioglass also called a bioactive glass has an inherent osteogenic potential, thus, provide new strategies to regenerate diseased or lost bone with minimum exposure to multiple materials. This article covers the systematic review of all the research done on bioglass and osteogenesis since 2007 till present on PubMed based on the eligibility criteria. The main objectives of the study were to evaluate the latest trend of bioglass research, to determine its osteogenic potential and to comprehend its possible clinical applications. Increasing trend is observed towards the in vivo research of bioglass for its osteogenic potential and effective clinical applications. In the field of dentistry, the use of bioglass is identified in quick healing and regeneration of intrabony defects especially the periodointium with a potential application in periodontology and maxillofacial surgery. Bioglass is a more potent and cheap alternative to bone implantation and transplantation with minimum side effects and efficient replacement with body's own new regenerated tissue
ABSTRACT
Agents of choice may be introduced in to the mouth via dental restorations, but this concept is only in embryonic stages and needs to be explored, modified, controlled and gauged to make it useful. This study aims at indicating the common therapeutic agents that are being delivered via dental restorations, modern restorative materials successfully delivering agents, and methods of agent incorporation; elaborating the potential for future use of such systems. Relevant publications from the last fifty years were included by searching 'dental restorations', and 'drug delivery systems' via [Mesh terminology]. Specific exclusion and inclusion criteria were set. It was found that the arena of drug delivery via dental restorations seems to be restricted to fluoride, the most commonly delivered agent via restorations. Glass ionomer cements including resin modified GICs; composites including compomers, and nanocomposites; and to some extent amalgam are the materials being researched upon. Although most research surrounds systems that rely upon recharge, modern microcapsules have been designed that can be used to incorporate the agent into the restoration. There is a dearth of work been done on the factors affecting the delivery of agents. So far, the dicalcium phosphate anhydrous [DCPA] incorporated nanocomposite is the most promising fluoride-delivering restorative material with a competent blend of fluoride releasing and mechanical properties. DCPA-incorporated nanocomposite and ion impregnable microcapsules are new horizons for drug delivery using dental restorations